史笑梅

史笑梅，理学博士

Email: shixiaomei@cczu.edu.cn

教育及工作经历：

2023.10—至今：常州大学医学与健康工程学院，讲师

2021.4—2023.3：南京大学化学化工学院，博士后

2017.9—2020.12：南京大学化学化工学院，博士研究生（导师：陈洪渊院士）

研究方向：

单细胞电分析

有机光电化学晶体管生物传感

主要科研项目：

中国博士后科学基金面上资助，2021.1-2023.10，主持

江苏省卓越博士后计划，2021.4-2023.3，主持

常州市领军型创新人才引进培育项目，2023.11-2025.11，主持

南京大学研究生科研创新项目，2017.9-2019.8，主持

国家自然科学基金面上项目，2020.1-2023.12，参与

代表性论文及科研成果：

[1].Xiao-Mei Shi, Yi-Tong Xu, Bing Wang, Zheng Li, Si-Yuan Yu, Hang Dong, Wei-Wei Zhao*, Dechen Jiang, Hong-Yuan Chen, Jing-Juan Xu*. An Integrated Dual-Functional Nanotool Capable of Studying Single-Cell Epigenetics and Programmable Gene Regulation, Angewandte Chemie International Edition, 2023, 62 (29), e202302930.

[2].Xiao-Mei Shi, Yi-Tong Xu, Bing-Yu Zhou, Bing Wang, Si-Yuan Yu, Wei-Wei Zhao*, Dechen Jiang, Hong-Yuan Chen, Jing-Juan Xu*. Electrochemical Single-Cell Protein Therapeutics Using a Double-Barrel Nanopipette, Angewandte Chemie International Edition, 2023, 62 (9), e202215801.

[3].Xiao-Mei Shi, Yi-Fan Ruan, Hai-Yan Wang, Wei-Wei Zhao*, Jing-Juan Xu, Hong-Yuan Chen*. A Supersmall Single-Cell Nanosensor for Intracellular K⁺ Detection, CCS Chemistry, 2020, 2 (9), 2359-2367.

[4].Xiao-Mei Shi, Fang-Qing Liu, Bing Wang, Si-Yuan Yu, Yi-Tong Xu, Wei-Wei Zhao*, Dechen Jiang, Hong-Yuan Chen, Jing-Juan Xu*. Functional Nucleic Acid Engineered Double-Barreled Nanopores for Measuring Sodium to Potassium Ratio at Single-Cell Level, Exploration, 2022, 2 (5), 20220025.

[5].Xiao-Mei Shi, Zhen Wang, Miao-Hua Chen, Qing-Qing Wu, Feng-Zao Chen, Gao-Chao Fan*, Wei-Wei Zhao*. Highly Light-Harvesting MOF-on-MOF Heterostructure: Cascading Functionality to Flexible Photogating of Organic Photoelectrochemical Transistor and Bienzyme Cascade Detection, Analytical Chemistry, 2024, 96 (8), 3679-3685.

[6].Xiao-Mei Shi, Chao-De Wang, Yuan-Cheng Zhu, Wei-Wei Zhao*, Xiao-Dong Yu*, Jing-Juan Xu, Hong-Yuan Chen*. 3D Semiconducting Polymer/Graphene Networks: Toward Sensitive Photocathodic Enzymatic Bioanalysis. Analytical Chemistry, 2018, 90 (16), 9687-9690.

[7].Xiao-Mei Shi, Li-Ping Mei, Nan Zhang, Wei-Wei Zhao*, Jing-Juan Xu, Hong-Yuan Chen*. A Polymer Dots-Based Photoelectrochemical pH Sensor: Simplicity, High Sensitivity, and Broad-Range pH Measurement. Analytical Chemistry, 2018, 90 (14), 8300-8303.

[8].Xiao-Mei Shi, Li-Ping Mei, Qian Wang, Wei-Wei Zhao*, Jing-Juan Xu, Hong-Yuan Chen*. Energy Transfer between Semiconducting Polymer Dots and Gold Nanoparticles in a Photoelectrochemical System: A Case Application for Cathodic Bioanalysis. Analytical Chemistry, 2018, 90 (7), 4277-4281.

[9].Xiao-Mei Shi, Gao-Chao Fan, Qingming Shen*, Jun-Jie Zhu*. Ultrasensitive Photoelectrochemical Biosensor for the Detection of HTLV-I DNA: A Cascade Signal Amplification Strategy Integrating λ-Exonuclease Aided Target Recycling with Hybridization Chain Reaction and Enzyme Catalysis. Biosensors and Bioelectronics, 2018, 109, 190-196.

[10].Xiao-Mei Shi, Gao-Chao Fan, Qingming Shen*, Jun-Jie Zhu*. Photoelectrochemical DNA Biosensor Based on Dual Signal Amplification Strategy Integrating Inorganic-Organic Nanocomposites Sensitization with λ-Exonuclease Assisted Target Recycling. ACS Applied Materials and Interfaces, 2016, 8 (51), 35091-35098.

[11].Yibin Lu, Xueyu Lu, Xiao-Mei Shi*, Gao-Chao Fan*. Enhanced Two-Electrode Photoelectrochemical Biosensing Platform Amplified by Bilirubin Oxidase Labelling. Sensors and Actuators: B. Chemical, 2021, 343, 130060.

[12].Shiting Gu, Xiao-Mei Shi (co-first author), Di Zhang, Gao-Chao Fan*, Xiliang Luo*. Peptide-Based Photocathodic Biosensors: Integrating a Recognition Peptide with an Antifouling Peptide. Analytical Chemistry, 2021, 93 (4), 2706-2712.

[13].Ling Zhang, Xiao-Mei Shi (co-first author), Xiao-Dong Yu*, Yan-Yu Liang*, Wei-Wei Zhao*. Binding-Induced Formation of DNAzyme on an Au@Ag Nanoparticles/TiO₂ Nanorods Electrode: Stimulating Biocatalytic Precipitation Amplification for Plasmonic Photoelectrochemical Bioanalysis. Biosensors and Bioelectronics, 2019, 134, 103-108.

[14].Nan Zhang, Xiaomei Shi (co-first author), Hong-Qian Guo, Wei-Wei Zhao*, Jing-Juan Xu, Hong-Yuan Chen*. Gold Nanoparticle Couples with Entropy-Driven Toehold-Mediated DNA Strand Displacement Reaction on Magnetic Beads: Toward Ultrasensitive Energy-Transfer-Based Photoelectrochemical Detection of miRNA-141 in Real Blood Sample. Analytical Chemistry, 2018, 90 (20), 11892-11898.

[15].Yi-Fan Ruan, Xiao-Mei Shi, Hai-Yan Wang, Wei-Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen*. CdS Quantum Dots Modified Photoelectrochemical Biosensor for TATA-Binding Protein Probing. Methods in Molecular Biology, 2020, 2135, 237-247.

[16].Ling Zhang, Xiao-Mei Shi, Yi-Tong Xu, Gao-Chao Fan, Yan-Yu Liang*, Chengshuang Wang*, Wei-Wei Zhao*. Gold Nanoparticle-Induced Photocurrent Quenching and Recovery of Polymer Dots: Toward Signal-On Energy-Transfer-Based Photocathodic Bioanalysis of Telomerase Activity in Cell Extracts. Analytical Chemistry, 2019, 91 (10), 6403-6407.

[17].Gao-Chao Fan, Xiao-Mei Shi, Jian-Rong Zhang*, Jun-Jie Zhu*. Cathode Photoelectrochemical Immunosensing Platform Integrating Photocathode with Photoanode. Analytical Chemistry, 2016, 88 (21), 10352-10356.

[18].Yi-Fan Ruan, Hai-Yan Wang, Xiao-Mei Shi, Yi-Tong Xu, Xiao-Dong Yu, Wei-Wei Zhao*, Hong-Yuan Chen, Jing-Juan Xu*. Target-Triggered Assembly in a Nanopipette for Electrochemical Single-Cell Analysis. Analytical Chemistry, 2021, 93 (2), 1200-1208.

[19].Tian-Yang Zhang, Si-Yuan Yu, Bing Wang, Yi-Tong Xu, Xiao-Mei Shi, Wei-Wei Zhao*, Dechen Jiang, Hong-Yuan Chen, Jing-Juan Ju*. A High Spatiotemporal Iontronic Single-Cell Viscometer. Research, 2022, 2022, 9859101.

[20].Hai-Yan Wang, Yi-Tong Xu, Bing Wang, Si-Yuan Yu, Xiao-Mei Shi, Wei-Wei Zhao*, Dechen Jiang, Hong-Yuan Chen, Jing-Juan Xu*. A Photoelectrochemical Nanoreactor for Single-Cell Sampling and Near Zero-Background Faradaic Detection of Intracellular microRNA. Angewandte Chemie International Edition, 2022, 61 (47), e202212752.