魏然

魏然博士硕士生导师 江苏省“双创博士”

E-mail: weiran@cczu.edu.cn

教育经历

Ø 2012.09-2015.12 英国贝尔法斯特女王大学  药学  博士（直博）

Ø 2008.09-2012.06 福州大学  生物工程  本科  

工作经历：

Ø 2020.11-今          常州大学  医学与健康工程学院  讲师

Ø 2016.02-2020.10     澳门大学 健康科学学院 博士后研究员

Ø 2013.09-2015.09     英国贝尔法斯特女王大学 博士生研究助理

社会兼职

担任International journal of biological science （SCI, IF=10.50）、Frontiers in molecular biosciences (SCI, IF=5.26)、Frontiers in chemistry（SCI, IF=3.99）等杂志编委会审稿人。2022年受邀担任Technology in cancer research & treatment杂志编辑。

2021年作为访问学者到访澳门大学健康科学学院，参加学术会议。

主要研究方向

癌症精准医学；肿瘤细胞学；分子生物学；肿瘤标志物研究；生物信息学；蛋白质组学；天然多肽药物开发

发表论文：

1. Wei R, Wu Q, Ai N, Wang L, Zhou M, Shaw C, Chen T, Ye RD, Ge W, Siu SW, Kwok HF. A novel bioengineered fragment peptide of Vasostatin-1 exerts smooth muscle pharmacological activities and anti-angiogenic effects via blocking VEGFR signalling pathway. Computational and Structural Biotechnology Journal. 2021 May 3（IF：7.271；JCR分区：Q1）.

2. Wei R, Guo L, Wang Q, Miao J, Kwok HF, Lin Y. Targeting PD-L1 Protein: Translation, Modification and Transport. Current Protein and Peptide Science. 2019 Jan 1;20(1):82-91（IF：3.376; JCR分区：Q3）.

3. Wei R, Wong JP, Lyu P, Xi X, Tong O, Zhang SD, Yuen HF, Shirasawa S, Kwok HF. In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer. Journal of cellular and molecular medicine. 2018 Sep;22(9):4097-4105(IF：5.31；JCR分区：Q1).

4. Wong JP^#, Wei R^#, Lyu P, Tong OL, Zhang SD, Wen Q, Yuen HF, El-Tanani M, Kwok HF. Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer. International journal of biological sciences. 2017 Nov 1;13(11):1373-1386(IF：10.50；JCR分区：Q1).

5. Wei R, Wong JP, Kwok HF. Osteopontin--a promising biomarker for cancer therapy. Journal of Cancer. 2017 Jul 15;8(12):2173-2183(IF：4.478；JCR分区：Q2).

6. Xie J, Chen P, Xie H, Sun Y, Huang Z, Wei R, Miao Z, Wang Q, Zhang SD, Wong KH, Lin Y. Exploration of gastric neuroendocrine carcinoma (GNEC) specific signaling pathways involved in chemoresistance via transcriptome and in vitro analysis. Computational and structural biotechnology journal. 2020 Jan 1;18:2610-20(IF：7.271；JCR分区：Q1).

7. Guo L, Wei R, Lin Y, Kwok HF. Clinical and Recent Patents Applications of PD-1/PD-L1 Targeting Immunotherapy in Cancer Treatment—Current Progress, Strategy and Future Perspective. Frontiers in Immunology. 2020; Nov:1508(IF：7.561；JCR分区：Q1).

8. Lyu P, Ge L, Ma R, Wei R, McCrudden CM, Chen T, Shaw C, Kwok HF. Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide–PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer. Scientific reports. 2018 Sep 28;8(1):14502-14512(IF：5.133; JCR分区：Q1).

9. Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C. Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities. Biochimie. 2013 Sep 1;95(9):1784-1794(IF：4.079；JCR 分区：Q2).

会议摘要

1. Wei R, Wu Q, Ai N, et al. A novel bioengineered fragment peptide of Vasostatin-1 exerts smooth muscle pharmacological activities and anti-angiogenic effects via blocking VEGFR signalling pathway (2021), 8^th Macau Symposium on Biomedical Sciences 2021, Faculty of Health Sciences, University of Macau, 23^rd&24^rd July 2021.

2. Wei R, Shan Y, Lyu P, et al. ADAMTS5—a novel & precision target in ovarian cancer treatment (2020), 4th Symposium on Biomedical sciences for students, postdoctoral fellows and research assistant, University of Macau, 15^th May 2020.

3. Wei R, Wong JP, Lyu P, et al. In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer (2019), 6th Macau Symposium on Biomedical Sciences 2019, Faculty of Health Sciences, University of Macau, 12^th &13^th June 2019.

4. Wei R, Shaw C, Chen T. Peptidomic and Bioinformatic Studies on Neuroendocrine Tumour Cells (2015) 37^th All Ireland schools of Pharmacy conference. School of Pharmacy, Queen’s University Belfast. 30^th &31^th March 2015.