蔡志强

浙江大学生物物理学博士，江苏省“333高层次人才培养工程”第三层次培养对象，江苏省生物技术协会常务理事，省生物技术协会青年专家委员会副主任委员，中国印染行业协会理事。主要从事应用现代生物技术、生物催化、发酵工程和环境微生物等方面的研究，主持国家、省部级及企业开发项目30多项，在国内外重要期刊上发表研究论文70多篇，申请发明专利12件，主编出版教材2部，《生物化学》为“十三五”江苏省高等学校重点教材，江苏省一流课程《重组菌发酵生产γ-氨基丁酸虚拟仿真实验》负责人，2019年、2021年连续获得常州大学教学成果一等奖，常州大学2014-2016年度优秀共产党员，2020年获第二届常州大学教学名师培育对象，2021年常州大学优秀教育工作者，2022年常州大学师德标兵。常州大学应用微生物与生物技术团队负责人。

联系方式：江苏常州武进区滆湖中路21号，常州大学医学与健康工程学院

电话/传真：0519-86330256  邮编213164

Email: zhqcai@cczu.edu.cn

课题组主要成员：

郭 静博士（guojing113@cczu.edu.cn）

洪婷婷博士（hongtingting@cczu.edu.cn）

满在伟博士（mzw@cczu.edu.cn）

敖 大博士（da_ao@cczu.edu.cn）

岳纹龙博士（136561350@qq.com）

朱孝霖讲师（skylin09@126.com）

主要研究项目

1. 国家自然科学基金面上项目（11275033），主持人；

2. 江苏省自然科学基金面上项目（BK20151185），主持人；

3. 江苏省333人才培养工程；

4. 2015江苏省企业博士聚集计划；

5. 常州市社会发展项目（常州黑牡丹股份有限公司）：高效硫氧化微生物菌剂的构建及其应用；

6. 光宝科技（常州）有限公司：天亮临床化学多项联合检测试剂试制评估；

7. 中国石化：高效硝化微生物菌剂的构建及其应用；

8. 江苏慧聚药业有限公司：生物法拆分手性环己烯甲酸制备S-CHCA；

9. 江苏悠恒生物有限公司：脂肪酶催化制备D-泛醇16迷粽榈酸单酯；

10. 江苏悠恒生物有限公司：果胶酶高产菌种选育及发酵生产酶制剂关键技术；

11. 茂名石化：高效硝化菌的中试应用研究；

12. 云汇环保科技南通有限公司：氯苯和苯乙烯气体生物除臭微生物菌剂的研发及应用

授课经历: 

1.        微生物学，本科生

2.        高级微生物学，研究生

近年来发表的代表性学术论文:

40. Zhu Xiaolin, Zhiqiang Cai*et al. Improvement of Biosynthetic Ansamitocin P-3 Production Based on Oxygen-Vector Screening and Metabonomics Analysis.Evidence-Based Complementary and Alternative Medicine. 2022. https://doi.org/10.1155/2022/3564185.

39. Guo Jing, Zhiqiang Cai*et al. Gene Cloning, Functional Expression, and Characterizationof a Novel GH46 Chitosanase from Streptomyces avermitilis (SaCsn46A).Applied Biochemistry and Biotechnology. 2022. 194:813-826.

38. Hong Tingting, Zhiqiang Cai, et al. What the Microscale Systems “See” In Biological Assemblies: Cells and Viruses? Analytical chemistry 2022, 94, 59−74.

37. 金毅，蔡志强*等. 微流控流体动力聚焦技术制备的脂质体及其靶向乳腺癌的新策略. 中国医药工业杂志，2022, 53(6): 11-20.

36. 罗雯，蔡志强*等. 果胶酶生产菌株的筛选、发酵优化及其酶学性质研究. 食品科技，2022, 47(4): 6-13.

35. Guo Jing, Zhiqiang Cai*et al. Screening of three ammonia-oxidizing bacteria and construction of compounding agent CCZU C6 in high-efficiency ammonia-oxidizing.Journal of Water Process Engineering. 2021. 40:101862.

34. Zhang Yi, Zhiqiang Cai, et al. Recent advances in 3D bioprinting of vascularized tissues. Materials and Design. 2021, 109398.

33. Hong Tingting, Zhiqiang Cai, et al. How does DNA ‘meet’ capillary-based microsystems? Analyst. 2021, 146:48-63.

32. Mingjing Ke, Zhiqiang Cai, et al. Leaf metabolic influence of glyphosate and nanotubes on the Arabidopsis thaliana phyllosphere. Journal of Environmental Sciences. 2021, 106:66–75.

31. 仲文雅，俞汶佳，谷艺明，郭静，樊博，蔡志强*，生物合成安丝菌素的研究进展. 化工进展，2021, 40(2): 990-997.

30. Zaiwei Man , Jing Guo , Yingyang Zhang, Zhiqiang Cai*. Regulation of intracellular ATP supply and its application in industrial biotechnology, Critical Reviews in Biotechnology, 2020, 40(8):1151-1162.

29. Tao Lu, Zhiqiang Cai*, et al. Insights into the transcriptional responses of a microbial community to silver nanoparticles in a freshwater microcosm. Environmental Pollution. 258(2020):113727.

28. 吴兴可，蔡志强*等珍贵橙色束丝放线菌发酵产安丝菌素P-3 的分离纯化工艺优化. 化工进展，2020, 39(3):1122-1128.

27. Wenxing Song, Zhiqiang Cai, et al. Magnetic-silk/polyethyleneimine core-shell nanoparticles for targeted gene delivery into human breast cancer cells. International Journal of Pharmaceutics 555 (2019) 322–336.

26. Wenxing Song, Zhiqiang Cai, et al. Magnetic Alginate/Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells. Nanomaterials. 2018, 8: 907; doi:10.3390/nano8110907.

25. Yi Zhang, Zhiqiang Cai, et al. Film bulk acoustic resonators (FBARs) as biosensors: A review. Biosensors and Bioelectronics. 116(2018):1-15.

24. Tingting Bian, Ziheng Zhuang, Xiaolin Zhu, Jing Guo, Zhiqiang Cai*, Xiubo Zhao.Toxic effect of the novel chiral insecticide IPP and its biodegradation intermediate in nematode Caenorhabditis elegans. Ecotoxicology and Environmental Safety. 164 (2018) 604--610.

23. 张宇，蔡志强*等，磁性材料固定化脂肪酶的制备及其催化性能研究，常州大学学报，2018，30(4):28-35.

22. 周少敏，蔡志强*等，橙色珍贵束丝放线菌固体发酵合成安丝菌素P-3的工艺探索，化工进展，2018，37(12):4837-4843；

21. 荣艳，郭静，苏春，管义娜，朱孝霖，蔡志强等，安丝菌素P-3生产菌株Actinosynnema pretiosum ssp. auranticum的诱变育种及发酵培养基优化，化工进展，2018，37(10): 3988-3994；

20. Xiaolin Zhu, Shaomin Zhou, Jing Guo, Xiyue Zhao, Zhiqiang Cai*, Eukaryal composition and diversity in anaerobic soils influenced by the novel chiral insecticide Paichongding. AMB Express. 2018, 8:62.

19. Yan Rong, Yi Wang, Yina Guan, Zhiqiang Cai*,et al.Pyrosequencing reveals soil enzyme activities and bacterial communities impacted by graphene and its oxides. Journal of Agricultural and Food Chemistry. 2017, 65, 9191-9199.

18. Jie Chen, Shaomin Zhou, Zhiqiang Cai*,et al. Pyrosequencing reveals bacterial communities and enzyme activities differences after application of novel chiral insecticide Paichongding in aerobic soils. Applied Soil Ecology. 2017, 112:16-27.

17. Jing Wang, Jie Chen, Zhiqiang Cai*, et al. Isolation of the Novel Chiral Insecticide Paichongding (IPP) Degrading Strains and Biodegradation Pathways of RR/SS-IPP and SR/RS-IPP in an Aqueous System. Journal of Agricultural and Food Chemistry. 2016, 64, 7431−7437.

16.Zhiqiang Cai*, Jiangtao Ma, Jing Wang, et al. Aerobic biodegradation kinetics and pathway of the novel cis-nitromethylene neonicotinoid insecticide Paichongding in yellow loam and Huangshi soils. Applied Soil Ecology. 2016(98):150–158.

15. Zhiqiang Cai, Ma, Jiangtao; Wang,Jing,et al. Effects of the novel cis-nitromethylene neonicotinoid insecticide Paichongding on enzyme activities and microorganisms in yellow loam and Huangshi soils. Environmental Science and Pollution Research. 2016, 23:7786–7793.

14. Zhiqiang Cai*et al. Impact of the novel neonicotinoid insecticide Paichongding on bacterial communities in yellow loam and Huangshi soils. Environmental Science and Pollution Research. 2016 (23):5134–5142.

13. Xiaohong Chen, Zhiqiang Cai*. A fusant of Amycolatopsis sp. M3-1 and Pseudomonas sp. Nai8 with high capacity of degrading novel pyrimidynyloxybenzoic herbicide ZJ0273 and naphthalene.Environmental Science and Pollution Research. 2016(23):3517–3524.

12.Zhiqiang Cai*et al. Biodegradation of dye-containing wastewater by fusant strains using a sequential anaerobic–aerobic process.Desalination and Water Treatment, 2016(57):18888–18896.

11. Zhiqiang Cai, Wenjie Zhang, Shanshan Liet al. Microbial degradation mechanism and pathway of the novel insecticide Paichongding by a newly isolatedSphingobacterium sp. P1-3 from soil. Journal of Agricultural and Food Chemistry. 2015(63):3823−3829.

10. Zhiqiang Cai, Jing Wang, Jiangtao Ma, et al. Anaerobic Degradation Pathway of the Novel Chiral Insecticide Paichongding and Its Impact on Bacterial Communities in Soils. Journal of Agricultural and Food Chemistry. 2015(63):7151−7160.

9.Zhiqiang Cai*, Wenjie Zhang, Shanshan Liet al. Biodegradation of Azo Dye Disperse Orange S-RL by a Newly Isolated StrainAcinetobacter sp. SRL8.Water Environment Research, 2015, 87(6): 516-523.

8. Zhiqiang Cai et al. Effects of the novel pyrimidynyloxybenzoic herbicide ZJ0273 on enzyme activities, microorganisms and its degradation in Chinese soils.Environmental Science and Pollution Research. 2015(22):4425–4433.

7. Zhiqiang Cai et al. Biosynthesis of myristyl serinate by immobilized Candida antarcticalipase in two-phase system.Journal of Molecular Catalysis B: Enzymatic 2014(108):118–122.

6. Zhiqiang Cai et al. Aerobic biodegradation kinetics and pathway of the novel herbicide ZJ0273 in soils.European Journal of Soil Science. 2013(64):37-46.

5. Zhiqiang Cai et al. Microbial degradation characteristics and kinetics of novel pyrimidynyloxybenzoic herbicide ZJ0273 by a newly isolatedBacillus sp. CY.Environmental Science and Pollution Research. 2013(20): 8831-8838.

4. Zhiqiang Cai*, Qiaoli Chen, Haiyan Wang, et al. Degradation of the novel herbicide ZJ0273 byAmycolatopsis sp. M3-1 isolated from soil. Applied Microbiology and Biotechnology.2012, 96:1371-1379.

3. Zhiqiang Cai*, Lei Huang, Yucai He, et al. Enzyme catalysis and decolorization of brilliant reactive red X-3B by azoreductase from a newly isolatedPseudomonas putida WLY. Biology and Environment-Proceedings of the Royal Irish Academy.2012, 112B, 293-300.

2. 蔡志强，陈巧丽，赵希岳等. 拟无枝菌酸菌M3-1降解丙酯草醚的特性及应用初探. 高校化学工程学报，2012, 26(1):93-98.

1. 蔡志强*，杨百科，赵希岳等. 丙酯草醚降解菌CY的分离、鉴定及其降解特性. 环境化学. 2011, 30(8):1433-1438.

代表性专利和专著

15. 蔡志强 等，一种黑曲霉固态发酵产果胶酶的方法，国内发明专利，申请号：202111062610.0；

14. 蔡志强 等，一种氨氧化复合菌剂及其制备方法和应用，国内发明专利，申请号：202110774387.6；

13. 蔡志强，张宇等，一种同步纯化脂肪酶、酸性蛋白酶和α-淀粉酶的方法, 国内发明专利，申请号：201910941211.8；

12. 蔡志强，张宇等，一种高产脂肪酶酶活菌株的筛选方法, 国内发明专利，申请号：201910980977.7；

11. 蔡志强，殷鹏等，一株高效硫氧化菌在含硫化黑废水处理中的应用，国内发明专利，申请号：201811000737.8；

10. 蔡志强，周少敏等，一种安丝菌素P-3的提取与分离纯化方法，国内发明专利，申请号：201810033155.3；

9. 蔡志强，杨广花，朱孝霖，王国平.一种脂肪酶催化制备肉豆蔻醇丝氨酸酯的方法. 国内发明专利，发明专利证号：ZL 201210321681.2.

8. 蔡志强，朱孝霖，杨广花，王国平，赵希岳.一种脂肪酶催化制备D-泛醇16醚棕榈酸单酯的方法，发明专利，公开号：ZL 201210321618.9.

7. 李尔炀，蔡志强，杨广花，李亮.芽胞杆菌工程菌及其在油藏示踪和采油的应用.国内发明专利，发明专利证号：ZL 201010235088.7；

6.   蔡志强，等. 一种固定化脂肪酶催化合成L-丝氨酸十八醇酯的方法，发明专利，2013，中国，公开号：CN 103320479 A；

5.   蔡志强，等. 万古霉素菌株及其发酵产万古霉素的方法，发明专利，2012，中国，公开号：CN 102899268 A；

4.   蔡志强，等. 一株高温芽孢杆菌制备脂肽类生物表面活性剂的方法，发明专利，2011，中国，公开号: CN 102399847 A；

3. 蔡志强主编，《生物化学》，“十三五”江苏省高等学校重点教材，化学工业出版社.

2. 蔡志强主编. 《生物化学》, 化学工业出版社, 2010.

1. 王利群(主编)，蔡志强(副主编).《生物技术》, 东南大学出版社, 2010.