王翔

王翔，研究员，硕士生导师

E-mail：wangxiang@cczu.edu.cn

教育经历：

l  2001—2006：中国科学院生物物理研究所，生物物理学，获得博士学位

l  1997—2001：河北大学生命科学学院，微生物学，获得学士学位

工作经历：

l  2018—：常州大学生物医学工程与健康科学研究院，研究员

l  2011—2018：挪威卑尔根大学生物医学系，研究员

l  2010—2011：挪威卑尔根大学生物医学系，高级工程师

l  2007—2010：挪威卑尔根大学生物医学系，博士后

主要研究方向：

l  细胞间相互作用，以及群体细胞的力学生物学研究

l  微组织的力学生物学研究

l  微系统技术，如微流控、微结构在生物医学工程中的应用

代表性论文（第一及通讯作者论文）

1. Du R, Han X, Deng L*, Wang X*. Epithelial and mesenchymal phenotypes determine the dynamics of circulating breast tumor cells in microfluidic capillaries under chemotherapy-induced stress.  Biomicrofluidics. 18 (2024):024106.  (*通讯作者)

2. Wang Y, Han X, Deng L*, Wang X*. Tunneling nanotube-transmitted mechanical signal and its cellular response. Biochem Biophys Res Commun. 693 (2024):149368. (*通讯作者)

3. Han X, Xu L, Dou T, Du R, Deng L*, Wang X*. Inhibitory Effects of Epithelial Cells on Fibrosis Mechanics of Microtissue and Their Spatiotemporal Dependence on the Epithelial-Fibroblast Interaction. ACS Biomater Sci Eng. 9 (2023):4846. (*通讯作者)

4. Li A, Han X, Deng L*, Wang X*. Mechanical properties of tunneling nanotube and its mechanical stability in human embryonic kidney cells. Front Cell Dev Biol. 10 (2022):955676. (*通讯作者)

5. Wang X*, Gao Q, Han X, Bu B, Wang L, Li A, Deng L*. Sensitive detection of cell-derived force and collagen matrix tension in microtissues undergoing large-scale densification.  Proc Natl Acad Sci U S A. 118 (2021):e2106061118. (*通讯作者)

6. Han X, Wang X*. Opportunities and Challenges in Tunneling Nanotubes Research: How Far from Clinical Application?  Int. J. Mol. Sci. 22 (2021): 2306. (*通讯作者)

7. Wang X*, Deng L, Gjertsen BT. A microfluidic device for differential capture of heterogeneous rare tumor cells with epithelial and mesenchymal phenotypes. Anal Chim Acta 1129 (2020): 1-11. (*通讯作者)

8. Bittins M, Wang X*. TNT-Induced Phagocytosis: Tunneling nanotubes mediate the transfer of pro-phagocytic signals from apoptotic to viable cells. J Cell Physiol. 232 (2017): 2271-2279. (*通讯作者)

9. Wang X*, Gerdes HH. Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells. Cell Death Diff. 22 (2015): 1181-1191 (*通讯作者) (The Scientist 引用www.the-scientist.com/?articles.view/articleNo/43835/title/Mitochondria-Exchange/ )

10. Austefjord MW, Gerdes HH, Wang X*. Tunneling nanotubes: Diversity in morphology and structure. Commun Integr Biol. 7 (2014): e27934. (*通讯作者)

11. Andresen V*, Wang X*, Ghimire S, Omsland M, Gjertsen BT, Gerdes HH. Tunneling nanotube (TNT) formation is independent of p53 expression. Cell Death Diff. 20 (2013):1124. (*第一作者)

12. Wang X*, Bukoreshtliev NV, Gerdes HH. Developing neurons form transient nanotubes facilitating electrical coupling and calcium signaling with distant astrocytes. PLoS One. 7 (2012): e47429. (*第一作者)

13. Mandragon I, Wang X*, Gerdes HH*. Spatio-temporal analysis of tamoxifen-induced bystander effects in breast cancer cells using microfluidics. Biomicrofluidics. 6 (2012): 24128. (*通讯作者)

14. Wang X*, Gerdes HH. Long-distance electrical coupling via tunneling nanotubes. Biochim Biophys Acta Biomembrane. 1818 (2012): 2082-2086. (*第一作者)

15. Wang X*, Veruki ML, Bukoreshtliev NV, Hartveit E, Gerdes HH. Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels. Proc Natl Acad Sci U S A. 107 (2010):17194-17199. (*第一作者) (Nature报导引用www.nature.com/news/2010/100920/full/news.2010.482.html

a) www.nature.com/news/cell-biology-the-new-cell-anatomy-1.9476

b) www.nature.com/news/how-the-internet-of-cells-has-biologists-buzzing-1.22645)

16. Bukoreshtliev NV*, Wang X*, Hodneland E*, Gurke S, Barroso JF, Gerdes HH. Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells. FEBS Lett. 583 (2009):1481-1488. (*第一作者)

17. Wang X*, Zhao HF, Zhang GJ. Mechanism of cytosol phospholipase C and sphingomyelinase induced lysosome destabilization. Biochimie. 88 (2006): 913-922.(*第一作者)

18. Wang X*, Wang LL*, Zhang GJ. Guanosine 5’-[γ-thio]triphosphate-mediated activation of cytosol phospholipase C caused lysosomal destabilization. J. Membr. Biol. 211 (2006): 55-63. (*第一作者)

教学与科研项目：

l  项目负责人，国家自然科学基金面上项目（2020-2023）

l  项目负责人，江苏省自然科学基金面上项目（2019-2021）

l  项目负责人, Microfluidic device for rapid collection and phenotyping of circulating tumor cells (2016–2018)，挪威癌症学会.

l  博士后项目负责人, Cell-cell interactions during apoptosis of cancer cells (2013–2015)，挪威癌症学会.

l  实验项目负责人, Cell-cell interactions during apoptosis of cancer cells (2013–2016)，西挪威卫生局.

l  项目负责人, Cell-cell interactions during apoptosis of cancer cells (2012–2015)，挪威卑尔根研究基金会.

个人荣誉：

l  江苏省特聘教授，江苏教育厅，中国，2020.

l  Meltzers Grant. L. Meltzers Høyskolefond基金会,挪威, 2017.

l  Career Development Research Fellowship.挪威癌症学会,2016.

l  Meltzers Grant. L. Meltzers Høyskolefond基金会,挪威, 2013.

l  Young Researcher Fellowship in Translational Medicine.挪威卑尔根研究基金会, 2012.